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Top 10 Series: Sage Therapeutics

Jason Myhre
June 14, 2019 | 4 min read

One company in our Top 10* series is seeking to beneficially address a huge problem: depression. Their story began in 2015 with the development of a therapy to treat women suffering from postpartum depression (PPD), and now they are seeking to identify treatment for depression of all kinds...


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Company Name: Sage Therapeutics
Weight: 3.01% of Eventide Gilead (#7 of top 10 holdings)
Theme: Novel Neurology

Sage Therapeutics is seeking to beneficially address a huge problem: depression. Their story began in 2015 with the development of a therapy to treat women suffering from postpartum depression (PPD). During pregnancy, women have very high levels of allopregnanolone, a Novel Neurologynaturally occurring steroid in the body. The high levels of this steroid may contribute to oft-remarked ‘glow’ of expectant mothers, as it has a central nervous system effect of feeling happy. At birth, the levels of this steroid crash, which results in about one in four women experiencing some form of PPD (colloquially, ‘the baby blues’). Sage developed a treatment for PPD that intravenously delivers back this steroid with a more gradual taper, thereby alleviating the depression.

Since then, Sage has embarked on drug discovery to find a way to treat depression more broadly. By studying the way the PPD treatment worked, and how it binds to neurological receptors, Sage has found a small molecule which can be taken orally that uses the same mechanism of action with the same potential therapeutic benefit – but for depression of all kinds. Their new treatment is in clinical development. If successful, it would be the first major innovation in the treatment of depression since the 1990s. (Sage Therapeutics is based in Cambridge, MA.)

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*A "Top 10" series is a series of articles based on top 10 holdings of a fund by weight.

Holdings percentages are based on net assets as of December 31, 2018, selected based on portfolio weight. The opinions expressed herein are those of the fund’s investment team as of December 31, 2018, and subject to change.Reliance upon the views expressed herein is at the sole discretion of the reader. Holdings can change at any time and should not be considered investment advice. Historical holdings are provided for informational purposes to help explain Eventide's values-based investment process.  Eventide uses its trademark (“Investing that makes the world rejoice®”) in a figurative manner to help explain its focus on serving investors by helping to improve the world.

Mutual funds involve risk including the possible loss of principal. Past performance does not guarantee future results. The fund can invest in smaller-sized companies which may experience higher failure rates than larger companies and normally have a lower trading volume than larger companies. The fund’s ethical values screening criteria could cause it to under perform similar funds that do not have such screening criteria. The fund can have risk associated with the biotechnology and pharmaceutical industry in which these companies may be heavily dependent on clinical trials with uncertain outcomes and decisions made by the U.S. Food and Drug Administration. Companies in the technology industries have different risks including but not limited to products becoming obsolete, and entrance of competing products. Companies in the Industrials sector carry various risks including, but not limited to, risk related to debt loads and intense competition. The fund can have risk related to option investing. There are special risks associated with investments in foreign companies including exposure to currency fluctuations, less efficient trading markets, political instability and differing auditing and legal standards. The fund can invest in private companies. Private investments include various risks including but not limited to lack of liquidity, capital commitment risk, and valuation risk. Private companies may not be financially profitable and have uncertain futures, subjecting them to additional risks.

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4692-NLD-5/14/2019

Topic(s): Stories

Jason Myhre
Jason Myhre

Jason serves as Director of Marketing at Eventide. He is responsible for leading Eventide’s brand strategy, marketing, and corporate communications.